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Medi-Invest

Indication

Wrinkles

Not all wrinkles have the same cause. Fine lines and wrinkles in the skin itself improve with fractional resurfacing: non-ablative with the Mosaic 3D or the LaseMD Ultra, with little downtime, or ablative with the UltraClear or the eCO2 3D, which give a stronger effect but involve a longer recovery. Folds and sagging caused mainly by laxity, such as along the jawline, respond to skin tightening: needle-free radiofrequency with the XERF, or RF microneedling with the Genius.

UltraClear erbium fibre laser device for skin rejuvenation and resurfacing, with a modern touchscreen interface and medical treatment arm.
Acclaro

UltraClear

Skin quality improvementSkin rejuvenationSkin tightening+5

Why wrinkles form

Over the years, the dermis produces less collagen, and UV light damages the collagen and elastic fibres that remain. The skin becomes thinner, and lines that at first appeared only with facial expression stay visible at rest. At the same time, the skin loses firmness and folds form along the jawline. Dynamic wrinkles such as frown lines are usually treated with botulinum toxin and are not covered here.

Wrinkles in the skin itself: fractional lasers

A fractional laser creates a grid of narrow columns in the skin. The intact skin in between lets the treated areas heal quickly and lay down new collagen. A non-ablative laser heats the columns without opening the skin; an ablative laser vaporises the tissue within them.

The Mosaic 3D (Er:glass, 1550 nm) and the LaseMD Ultra thulium laser (1927 nm) are non-ablative. The Mosaic 3D reaches into the dermis; the LaseMD Ultra works more superficially and also improves dull skin tone and pigmentation. In a comparative study, wrinkles improved more with non-ablative 1550 nm Er:glass, the Mosaic 3D's wavelength, than with an ablative fractional Er:YAG laser. This approach takes more sessions, each with a short recovery.

On the ablative erbium fibre laser UltraClear, coagulation is adjustable alongside ablation, so treatment ranges from light to deep resurfacing. After a deeper treatment, recovery usually takes around five days. The CO₂ laser eCO2 3D leaves the most heat around each column, so the surrounding collagen contracts as well. The trade-off is the longest recovery: according to Cynosure Lutronic, redness after deeper resurfacing can last a week or longer. In darker skin, post-inflammatory hyperpigmentation (PIH) is the main risk of ablative treatment.

Folds from skin laxity: tightening with radiofrequency

A fold caused by laxity needs heat in a larger volume of tissue, without opening the skin. That is what monopolar RF provides: the current flows from a single electrode on the skin through the dermis and the connective tissue beneath it, heating that volume. The collagen contracts immediately and is remodelled over the following months, so tightening continues to improve. Because RF does not act on melanin, skin colour plays a much smaller role.

The XERF uses two frequencies and three depth modes, continuously measures the impedance of the skin and cools the surface during treatment. In one study, the eyebrow and upper eyelid were measurably higher one and three months after treatment. Redness and swelling usually resolve within a day. The XERF suits mild to moderate laxity of the jawline, the cheeks and the skin around the eyes, in patients who want to be back to normal quickly.

In RF microneedling with the Genius, insulated needles deliver the current into the dermis at a chosen depth. Because the needles also create tiny wounds, the treatment addresses texture and fine lines as well as laxity. Redness and swelling settle within a few days.

Wrinkle treatment in your practice

If you mainly see patients with fine lines and photodamage who want little downtime, a non-ablative laser such as the Mosaic 3D is a logical first step. If you also want to treat deeper wrinkles, the UltraClear or the eCO2 3D adds ablative treatment. If you see many patients with a lax jawline or cheeks, the XERF complements this without needles. Some practices also combine the XERF with the LaseMD Ultra, in a separate session, for texture and pigmentation.

We will go through your patients and your existing equipment with you. After installation, we provide clinical training, treatment protocols and technical support. You can buy a device outright or lease it.

Technologies for this indication

  • CO₂ laser (10,600 nm)

    CO₂ works on wrinkles in two ways: the laser vaporises the upper layers, and the heat makes collagen contract and then be renewed. In older studies, fully ablative CO₂ clearly improved wrinkles around the eyes and mouth [1], but the skin stayed red for months on average [2]. In fractional mode, the effect per session is smaller, and so is the downtime [3]. After three sessions of fractional CO₂, wrinkles were measurably smaller and less deep, most markedly on the cheeks and around the eyes [4]. Around the eyes, fractional CO₂ and fractional Er:YAG gave a comparable effect after one session [5].

  • Erbium

    For fine wrinkles, ablative erbium works by resurfacing; for deeper wrinkles, through channels into the dermis. In an older comparison of non-fractional treatments, CO₂ worked better than Er:YAG on moderate and deep wrinkles around the eyes and mouth [6]. In a randomised study, wrinkles improved more with non-ablative 1550 nm Er:glass than with fractional Er:YAG [7]. Advanced photoageing with wrinkles improved with the 2910 nm erbium fibre laser [8].

  • Monopolar RF

    Monopolar RF addresses wrinkles mainly by tightening the skin. Older studies report fewer fine lines around the eyes [9], and in the clinical study of XERF wrinkles also improved [10].

  • RF microneedling

    RF microneedling works on wrinkles because the dermis produces new collagen and elastin [11]. In a prospective study of 25 patients with wrinkles around the eyes, image analysis showed the wrinkles became less deep on average, most markedly at the crow's feet. The blinded assessors saw a variable improvement. Redness and swelling resolved within a few days. The authors call for larger, comparative studies [12].

Which device suits your practice?

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References

  1. Fitzpatrick RE, Goldman MP, Satur NM, Tope WD. Pulsed Carbon Dioxide Laser Resurfacing of Photoaged Facial Skin. Arch Dermatol. 1996;132(4):395–402. doi:10.1001/archderm.1996.03890280047007
  2. Nanni CA, Alster TS. Complications of Carbon Dioxide Laser Resurfacing. An Evaluation of 500 Patients. Dermatol Surg. 1998;24(3):315–320. doi:10.1111/j.1524-4725.1998.tb04161.x
  3. Preissig J, Hamilton K, Markus R. Current Laser Resurfacing Technologies: A Review that Delves Beneath the Surface. Semin Plast Surg. 2012;26(3):109–116. doi:10.1055/s-0032-1329413
  4. Kohl E, Meierhöfer J, Koller M, Zeman F, Klein A, Hohenleutner U, Landthaler M, Hohenleutner S. Fractional carbon dioxide laser resurfacing of rhytides and photoageing: a prospective study using profilometric analysis. Br J Dermatol. 2014;170(4):858–865. doi:10.1111/bjd.12807
  5. Karsai S, Czarnecka A, Jünger M, Raulin C. Ablative fractional lasers (CO2 and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides. Lasers Surg Med. 2010;42(2):160–167. doi:10.1002/lsm.20879
  6. Adrian RM. Pulsed carbon dioxide and erbium-YAG laser resurfacing: a comparative clinical and histologic study. J Cutan Laser Ther. 1999;1(1):29–35. doi:10.1080/14628839950517066
  7. Moon HR, Yun WJ, Lee YJ, Lee MW, Chang S. A prospective, randomized, double-blind comparison of an ablative fractional 2940-nm erbium-doped yttrium aluminum garnet laser with a nonablative fractional 1550-nm erbium-doped glass laser for the treatment of photoaged Asian skin. J Dermatolog Treat. 2015;26(6):551–557. doi:10.3109/09546634.2014.999020
  8. Murray TN, Hu JK, Friedman PM. Full-face and neck resurfacing with a novel ablative fractional 2910 nm erbium-doped fluoride glass fiber laser for advanced photoaging. Lasers Surg Med. 2024;56(3):249–256. doi:10.1002/lsm.23764
  9. Fitzpatrick R, Geronemus R, Goldberg D, Kaminer M, Kilmer S, Ruiz-Esparza J. Multicenter study of noninvasive radiofrequency for periorbital tissue tightening. Lasers Surg Med. 2003;33(4):232–242. doi:10.1002/lsm.10225
  10. Erlich G, Dahan E, Wolf Y. Objective and subjective retrospective evaluation of XERF, a novel single-shot dual-frequency non-invasive monopolar radiofrequency. Lasers Med Sci. 2026;41(1):194. doi:10.1007/s10103-026-04996-0The lead author is a trainer for Cynosure Lutronic; the manufacturer performed the statistical analysis.
  11. Hantash BM, Ubeid AA, Chang H, Kafi R, Renton B. Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis. Lasers Surg Med. 2009;41(1):1–9. doi:10.1002/lsm.20731Different device (bipolar, with needles and temperature feedback).
  12. Nguyen L, Dierickxsens C, Schneider SW, Karsai S, Herberger K. Radiofrequency microneedling for skin rejuvenation of the periorbital region – a prospective, clinical study. J Cosmet Laser Ther. 2026;28(1–5):35–39. doi:10.1080/14764172.2026.2680304Same research group as the Genius studies; the abstract does not name the device.

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