Technology · No chromophore
How does RF microneedling work in the skin?
In RF microneedling, fine needles enter the skin and deliver radiofrequency current into the dermis. Small zones of coagulated tissue form around the needle tips, while the epidermis is largely spared. As those zones heal, the skin produces new collagen and elastin. You would use it mainly for acne scars, irregular texture and laxity. We supply Genius from Cynosure Lutronic, a device with insulated needles that works in bipolar mode according to its FDA filings.
Clinically reviewed by Marit van Boldrik, Business & Clinicallast checked 19 October 2026
Translated from Dutch with the help of AI tools; the clinical review was carried out on the Dutch text.
Heat from electrical current
A laser needs a chromophore: a substance that absorbs the light. Radiofrequency does not: it is an alternating current that flows through the tissue. The tissue's resistance, its impedance, converts that current into heat [1]. How the current spreads beneath an electrode placed on the skin is explained on the monopolar RF page.
In RF microneedling, the needles themselves are the electrodes. They pass through the epidermis and deliver the energy directly into the dermis [1]. The heat is therefore generated at depth, around the needle, and not at the skin surface. A treatment thus leaves two kinds of tiny wounds: the needle punctures and, deeper down, the coagulation zones. According to a review article, it is precisely this heat that gives RF microneedling an advantage over microneedling without RF, especially for tightening; the article presents no data of its own [2].
Bipolar or monopolar
Where the heat is generated also depends on where the current flows. In bipolar RF microneedling, the current flows between the needles of the same tip, the disposable cartridge that holds the needles. Each needle is an electrode, and the current stays in the small area of skin beneath the tip. In an animal study, a separate coagulation zone formed in the dermis around each needle [3].
In monopolar RF, the current flows from one active electrode through the body to a neutral electrode: an adhesive pad placed elsewhere on the body [1][3]. Some RF microneedling systems also have a monopolar setting [1].
Genius works in bipolar mode, according to its 510(k) summaries at the US FDA. It delivers its energy at 460 kHz through tips that include one with 7 × 7 bipolar microneedles [4][5]. XERF, the other RF device we supply, works in monopolar mode and without needles: a cooled electrode on the skin heats a larger volume of tissue beneath it. That is a different treatment, aimed mainly at tightening. You can read more about it on the monopolar RF page.

Insulated and non-insulated needles
Where along the needle the current enters the tissue matters too. An insulated needle is shielded along almost its entire length; only the tip conducts. The energy is then released at the chosen depth, and the channel through the epidermis is spared [1]. With a non-insulated needle, the whole needle acts as the electrode [1]. In an animal study, the epidermis was largely spared with these needles as well, and the coagulation zones lay mainly in the dermis [3]. We found no clinical study directly comparing the two types of needle.
Genius uses insulated needles. According to the FDA summary, the tissue coagulates around the non-insulated part of the needle [4]; with insulated needles, that is the tip [1].
Depth and layer
Because the heat starts at the needle tip, the needle depth determines which layer you treat. According to a review article, the target is usually the reticular dermis, and the depth depends on skin thickness in the treatment area: shallower around the mouth than on the forehead [2]. Working in several passes at different depths places coagulation zones in layers one above the other [1]. In histological studies, greater needle depth and a longer pulse produced larger coagulation zones [1].
On the 2018 version of Genius, the needle depth is adjustable from 0.5 to 3.5 mm [4]; the version the FDA cleared in 2026 goes to 4 mm [5].

Energy and impedance
The energy per needle also matters, although it is linked to the pulse duration. In a study on ex vivo pig skin, the coagulation volume around the needle grew as the energy per needle rose. The device, a Genius, automatically lengthened the pulse at higher energies. One of the authors was technical director at the time at Lutronic; two others received speaker fees from the company [6].

How much heat a pulse actually produces also depends on the impedance of the tissue. It differs between the layers of the skin, between people and between sites on the body. It also changes during the pulse: warm tissue conducts better until it coagulates, but as soon as the water vaporises, the impedance rises sharply [1]. Newer RF microneedling devices therefore measure impedance during treatment [1]. As early as 2009, researchers described a needle-based device that measured temperature and impedance in real time to control energy delivery [7].
According to Cynosure Lutronic, Genius measures impedance and adjusts energy delivery about 500 times per second [8]. We are not aware of clinical studies comparing devices with and without such feedback. With a second pulse at the same spot and depth, the energy delivered is less predictable, because the impedance has changed [1]. The treatment protocols set out how to sequence passes and depths.
How the skin responds
After treatment, wound healing begins in the dermis. In biopsies after bipolar fractional RF with needles, the coagulation zones were still visible after four weeks and had been replaced by new tissue after ten weeks, with more collagen and elastin [9]. Clinically, too, the skin improves gradually, and the effect can still increase six months after treatment [10].
What it is used for
(Acne) scars
RF microneedling delivers heat through the needles into the dermis, where atrophic scars are located, and largely spares the epidermis. According to a systematic review of 16 studies with 481 patients, RF microneedling as monotherapy, without a combination treatment, is probably effective for acne scars; the authors do call for more randomised studies [11]. In two randomised split-face studies with fractional CO₂ as comparator, the scars improved to a similar degree on both sides. In one, RF microneedling was more painful during treatment and CO₂ caused more skin reactions [12]; in the other, the skin recovered faster after RF microneedling and there was less hyperpigmentation [13].
Skin tightening
RF microneedling heats the dermis at a chosen depth. In response, the skin produces new collagen and elastin and can gradually tighten. In a prospective study with Genius, 30 patients received one to three treatments of the lower face and neck. The researchers used submental volume as the measure of tightening, and it decreased on average. The physician, a blinded assessor and the patients themselves saw a clear improvement. The spread was large: in some patients the volume actually increased [14].
Skin quality improvement
Rough texture and enlarged pores are partly linked to the dermis beneath. RF microneedling renews the collagen there without damaging the entire epidermis. In a study of 30 patients with acne scars and enlarged pores, the pores and scars improved in more than 70% of patients. Skin surface roughness and dermal density also improved [15].
Wrinkles
RF microneedling works on wrinkles because the dermis produces new collagen and elastin [9]. In a prospective study of 25 patients with wrinkles around the eyes, image analysis showed the wrinkles became less deep on average, most markedly at the crow's feet. The blinded assessors saw a variable improvement. Redness and swelling resolved within a few days. The authors call for larger, comparative studies [16].
Stretch marks
With stretch marks, the aim is to remodel the collagen in the dermis. RF microneedling does this with small coagulation zones beneath the epidermis. In a meta-analysis, fractional RF microneedling gave an improvement comparable to fractional CO₂, according to practitioners and patients, with clearly less post-inflammatory hyperpigmentation [17].
Skin rejuvenation
Skin rejuvenation is about laxity, wrinkles and texture, but also about pigment and redness. RF microneedling acts mainly on the dermal component. In a study with Genius on the lower face and neck, hyperpigmentation improved only in the group that also received a 1927 nm fractional thulium laser (LaseMD Ultra). Submental volume decreased comparably in both groups. The groups were not randomised: the group with RF microneedling alone came from an earlier study [18]. The technologies for pigmented lesions are covered under pigmentation.
Dark skin
Here the main concern is the risk of pigmentary change. RF does not target melanin, and in RF microneedling the energy is released beneath the epidermis. RF microneedling is therefore regarded as a technique with a lower risk of pigmentary change in dark skin [19]. A systematic review of 35 studies of RF and RF microneedling in skin types III to VI found temporary post-inflammatory hyperpigmentation (PIH) in seven studies, mild, longer-lasting hyperpigmentation in one study and permanent scarring in one study. The authors describe the risk as low [19]. In comparative studies, PIH occurred less often than after fractional CO₂ [17][13]. PIH does occur after RF microneedling too, usually transiently [20].
The studies with Genius itself mainly involved patients with skin types II and III; skin types V and VI were not included. Even in that group, one patient developed temporary PIH after the first RF microneedling treatment [18]. Cynosure Lutronic describes Genius as safe for all skin types [8]. We are not aware of data on Genius in skin types V and VI.
Recovery and pain
Apart from the pigment risk, recovery is also a factor. Expect redness and swelling after treatment. In the systematic reviews, side effects were mostly mild and short-lived [21][20]. In a study with Genius, redness and swelling resolved within a few days [18]. Cynosure Lutronic cites 24 to 36 hours for mild redness and swelling, and up to a week for full recovery [8]. In a randomised comparison with fractional CO₂, redness, swelling and crusting were shorter-lived [13].
The treatment is painful. In one randomised comparison, RF microneedling was more painful during treatment than fractional CO₂ [12]; in the other, pain after RF microneedling was shorter-lived [13]. In a study with Genius, patients received a topical anaesthetic beforehand and still rated the pain at 5.6 out of 10 on average [18]. Discuss pain management with your patient beforehand.
In the same study, four of the 27 patients treated with RF microneedling alone developed perioral dermatitis; one of them also had a bruise at the orbital rim [18]. A scoping review points to a longer-term risk: RF microneedling can cause fibrosis and adhesions between tissue layers, which can complicate a later facelift. The authors recommend discussing this with patients who may consider a facelift in the future [22].
The studies with Genius excluded, among others, patients with a tendency to excessive scarring, with scars or lesions in the treatment area, or with recent surgery or injectable treatment [18]. The full list of contraindications is in the device manual.
Alongside other technologies
RF microneedling invites comparison with monopolar RF and with fractional lasers. Monopolar RF, which we offer as the XERF, heats a larger volume of tissue beneath the electrode without needles and reaches deeper than bipolar RF on the skin. RF microneedling combines tiny wounds from the needles with heat in the dermis [23]. In our view, this makes RF microneedling suitable for scars and texture as well, whereas monopolar RF is aimed mainly at tightening. We are not aware of direct comparisons between the two.
The fractional lasers in question are ablative CO₂ (eCO2 3D) and erbium, and non-ablative lasers at 1540–1550 nm (Mosaic 3D) and with thulium (LaseMD Ultra). A systematic review found four split-face studies in acne scars with a fractional laser as comparator or in combination. RF microneedling improved the scars, with shorter recovery than ablative CO₂ [24]. RF microneedling is also combined with a laser, for example with thulium when pigment is present as well [18].
RF microneedling has also been studied in active acne, melasma, rosacea and excessive sweating [10][20]. Those applications fall outside the scope of this page.
Research with Genius
Much has been published on RF microneedling, and there are several systematic reviews [10][11][21][20]. They are positive about efficacy and safety, but also point to weaknesses. Many studies are small and not randomised, they use different devices and settings, and they often report those settings incompletely [11][20]. Two of the most recent reviews are by authors who work or speak for Jeisys, a manufacturer of RF microneedling devices [21][20].
The clinical research with Genius comes mainly from one group in Hamburg [14][6][18]. According to the FDA, Genius is based on the same principle as its predecessor Infini, and both devices produced comparable coagulation zones in an animal study [4]; studies with the Infini therefore also shed light on the technology in Genius.
In summary: RF microneedling improves acne scars and texture. For scars, the effect in comparative studies comes close to that of fractional lasers; recovery is shorter than after ablative CO₂. For laxity, an effect is measurable, but it varies greatly between patients. In dark skin, the risk of pigmentary change is lower than with ablative CO₂, although PIH does occur after RF microneedling too.
Our devices using this technology
Advice
Is this technology right for your practice?
A single page cannot fully cover the choice between technologies. It depends on your patients and their skin types, the indications you want to treat, the recovery time your patients will accept and the equipment you already have. Our clinical and sales specialists have years of experience with that choice and are glad to help you make it.
Already working with one of our devices? You will find the treatment protocols and guidelines on the customer portal, and we go deeper into technique in the training after delivery and at our Academy events.
This is an indicative overview to explain how technologies differ. Actual settings are governed by the treatment protocols and guidelines.
References
- Chandra S, Mysore V, Shah S, Malayanur D, S R S. Physics of fractional microneedle radiofrequency – A review. J Cutan Aesthet Surg. 2024;17(3):177–183. doi:10.25259/jcas_98_23Narrative review.
- Shauly O, Marxen T, Menon A, Gould DJ, Miller LB, Losken A. Radiofrequency microneedling: technology, devices, and indications in the modern plastic surgery practice. Aesthet Surg J Open Forum. 2023;5:ojad100. doi:10.1093/asjof/ojad100Review article (level of evidence 5).
- Na J, Zheng Z, Dannaker C, Lee SE, Kang JS, Cho SB. Electromagnetic initiation and propagation of bipolar radiofrequency tissue reactions via invasive non-insulated microneedle electrodes. Sci Rep. 2015;5:16735. doi:10.1038/srep16735Animal study (minipig in vivo, bovine liver ex vivo).
- US Food and Drug Administration. 510(k) summary K180945: LUTRONIC GENIUS Radiofrequency System. FDA, 10 december 2018. https://www.accessdata.fda.gov/cdrh_docs/pdf18/K180945.pdfSummary submitted by the manufacturer.
- US Food and Drug Administration. 510(k) summary K253484: LUTRONIC GENIUS. FDA, 29 juni 2026. https://www.accessdata.fda.gov/cdrh_docs/pdf25/K253484.pdfSummary submitted by the manufacturer.
- Nguyen L, Bartholomeusz J, Schneider SW, Herberger K. Histological and clinical dose-response analysis of radiofrequency microneedling treatment for skin rejuvenation. Lasers Med Sci. 2025;40(1):75. doi:10.1007/s10103-025-04335-9With Genius; the device was provided by Lutronic. One author was technical director of Lutronic; the first and last authors received speaker fees from Lutronic.
- Hantash BM, Renton B, Berkowitz RL, Stridde BC, Newman J. Pilot clinical study of a novel minimally invasive bipolar microneedle radiofrequency device. Lasers Surg Med. 2009;41(2):87–95. doi:10.1002/lsm.20687
- Cynosure Lutronic. Genius RF microneedling (productpagina). cynosure.com, geraadpleegd op 17 oktober 2026. https://www.cynosure.com/product/genius/Manufacturer information.
- Hantash BM, Ubeid AA, Chang H, Kafi R, Renton B. Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis. Lasers Surg Med. 2009;41(1):1–9. doi:10.1002/lsm.20731Different device (bipolar, with needles and temperature feedback).
- Tan MG, Jo CE, Chapas A, Khetarpal S, Dover JS. Radiofrequency microneedling: a comprehensive and critical review. Dermatol Surg. 2021;47(6):755–761. doi:10.1097/DSS.0000000000002972
- Niaz G, Ajeebi Y, Alshamrani H, Khalmurad M, Lee K. Fractional radiofrequency microneedling as a monotherapy in acne scar management: a systematic review of current evidence. Clin Cosmet Investig Dermatol. 2025;18:19–29. doi:10.2147/CCID.S502295
- Hendel K, Karmisholt K, Hedelund L, Haedersdal M. Fractional CO2-laser versus microneedle radiofrequency for acne scars: a randomized, single treatment, split-face trial. Lasers Surg Med. 2023;55(4):335–343. doi:10.1002/lsm.23655
- Li W, Zheng C, Yuan X, Wu Z, Li C, Li C, Hu Z, Nie B, Shi Y, Yu Q. Comparative efficacy, recovery, and pigmentary safety of radiofrequency microneedling and fractional carbon dioxide laser for facial atrophic acne scars: a prospective randomized split-face trial. J Dermatolog Treat. 2026;37(1):2687842. doi:10.1080/09546634.2026.2687842
- Nguyen L, Blessmann M, Schneider SW, Herberger K. Radiofrequency microneedling for skin tightening of the lower face, jawline, and neck region. Dermatol Surg. 2022;48(12):1299–1305. doi:10.1097/DSS.0000000000003607With Genius, according to later publications from the same group.
- Cho SI, Chung BY, Choi MG, Baek JH, Cho HJ, Park CW, Lee CH, Kim HO. Evaluation of the clinical efficacy of fractional radiofrequency microneedle treatment in acne scars and large facial pores. Dermatol Surg. 2012;38(7 Pt 1):1017–1024. doi:10.1111/j.1524-4725.2012.02402.xNo control group.
- Nguyen L, Dierickxsens C, Schneider SW, Karsai S, Herberger K. Radiofrequency microneedling for skin rejuvenation of the periorbital region – a prospective, clinical study. J Cosmet Laser Ther. 2026;28(1–5):35–39. doi:10.1080/14764172.2026.2680304Same research group as the Genius studies; the abstract does not name the device.
- Aktoz F, Yilmaz N. Comparing fractional microneedle radiofrequency and fractional CO2 laser for striae distensae treatment: a systematic review and meta-analysis. Lasers Med Sci. 2024;39(1):271. doi:10.1007/s10103-024-04231-8
- Nguyen L, Blessmann M, Schneider SW, Herberger K. Radiofrequency microneedling with 1927 nm thulium laser versus radiofrequency microneedling monotherapy for rejuvenation of photoaged skin. J Cosmet Dermatol. 2026;25(1):e70685. doi:10.1111/jocd.70685With Genius and LaseMD Ultra, provided by Cynosure Lutronic; not randomised.
- Syder NC, Chen A, Elbuluk N. Radiofrequency and radiofrequency microneedling in skin of color: a review of usage, safety, and efficacy. Dermatol Surg. 2023;49(5):489–493. doi:10.1097/DSS.0000000000003733
- Kumar N, Kim HM, Nishikawa A, Heo CY, Wu WTL. Effectiveness of radiofrequency microneedling in the treatment of dermatological conditions: a systematic review. Aesthetic Plast Surg. 2026;50(13):5282–5317. doi:10.1007/s00266-026-05834-yThe first author is a consultant for Jeisys Medical; two other authors are speakers for Jeisys.
- Kumar N, Suh DH, Lee SJ, Kasif SA, Carruthers JDA. Radiofrequency microneedling for facial rejuvenation: a systematic review. J Cosmet Dermatol. 2026;25(4):e70845. doi:10.1111/jocd.70845Two authors work for Jeisys Medical, a manufacturer of RF microneedling devices; a third is a speaker for Jeisys.
- Panlilio M, Bolen R, Martini O, Bonk A, Tedesco J. Navigating the intersection of radiofrequency microneedling and surgical facelifts: scoping review. JMIR Dermatol. 2026;9:e78385. doi:10.2196/78385
- Zhang B, Tan X, Zhang Q, Wu M. The landscape of radiofrequency technology for skin rejuvenation. Health Sci Rep. 2026;9(1):e71575. doi:10.1002/hsr2.71575
- Cai W, Tang Z, Mu C. Microneedling radiofrequency versus fractional laser for the treatment of acne scars: a systematic review with descriptive quantitative synthesis. Aesthetic Plast Surg. 2026 (online 5 oktober 2026). doi:10.1007/s00266-026-06312-1